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Reproductive toxicology is one of the most complicated areas of toxicology research due to the involvement of multiple organs and tissues, different modes of toxicant action and dependence on the endocrine system. In particular, endocrine disrupters represent a significant challenge for experimental toxicology because of their complex effects on signal networks and programming. A variety of in vivo and in vitro developmental and reproductive toxicology (DART) tests are used to predict the safety of new compounds during drug development, and the results provide the basis for internal decision-making.
At Creative Bioarray, our DART capabilities include pharmaceuticals, biologics, vaccines, gene-therapy products, chemicals, and consumer products. Services cover the whole scope of developmental and reproductive toxicology from embryo fetal, postnatal and juvenile stages to the second generation, testing for the potential effects on fertility.