Authoring Question
T cells from a healthy patient′s blood are collected and are genetically modified to express an artificial receptor consisting of the variable fragment of an antibody specific for a cell surface molecule involved in T cell signaling. CAR-T cells are then propagated in cell culture until they reach several billions in number, and injected back into the patient′s blood stream. After infusion, CAR-T cells are designed to recognize tumor cells and kill them.