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Large-scale animal cell culture technology refers to the technology of high-density and large-scale cultivation of animal cells in a bioreactor to produce biological products under artificial conditions. Mammalian cells provide a good production system for complex biological products that require proper post-translational processing and folding. Generally speaking, the types of cells used for large-scale culture can be divided into two categories: cells that can grow in suspension (not dependent on anchoring) and cells that require physical support for growth (rely on anchoring). Many cell lines are available for production purposes and come from a variety of sources, thus exhibiting various growth and production characteristics. At present, large-scale cultured animal cells that are widely used in the production include CHO cells, Vero cells, etc., and have successfully produced products including vaccines, monoclonal antibodies and other products.



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