We just did a clean install on a new RHEL6 server, and WeBWorK came up cleanly. This is apache 2.2.15, perl 5.10.1 and mod_perl 2.0.4. What version of mod_perl do you have running? I am wondering if it's a problem with symlinks bug in version 2.0.2.
Failed installing webwork on Redhat Enterprise
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